Dr Thomas G. Egwang , B. Vet. Med, MSc, PhD

 

Selected peer-reviewed Publications

 

1:

PfEMP1-DBL1alpha amino acid motifs in severe disease states of Plasmodium falciparum malaria.

Normark J, Nilsson D, Ribacke U, Winter G, Moll K, Wheelock CE, Bayarugaba J, Kironde F, Egwang TG, Chen Q, Andersson B, Wahlgren M.
Proc Natl Acad Sci U S A. 2007 Oct 2;104(40):15835-40. Epub 2007 Sep 25.
PMID: 17895392 [PubMed - indexed for MEDLINE]

2:

Quantitative trait loci controlling cyanogenic glucoside and dry matter content in cassava (Manihot esculenta Crantz) roots.

Balyejusa Kizito E, Rönnberg-Wästljung AC, Egwang T, Gullberg U, Fregene M, Westerbergh A.
Hereditas. 2007 Sep;144(4):129-36.
PMID: 17850597 [PubMed - indexed for MEDLINE]

3:

Genome wide gene amplifications and deletions in Plasmodium falciparum.

Ribacke U, Mok BW, Wirta V, Normark J, Lundeberg J, Kironde F, Egwang TG, Nilsson P, Wahlgren M.
Mol Biochem Parasitol. 2007 Sep;155(1):33-44. Epub 2007 May 18.
PMID: 17599553 [PubMed - indexed for MEDLINE]

4:

Genetic diversity and variety composition of cassava on small-scale farms in Uganda: an interdisciplinary study using genetic markers and farmer interviews.

Balyejusa Kizito E, Chiwona-Karltun L, Egwang T, Fregene M, Westerbergh A.
Genetica. 2007 Jul;130(3):301-18. Epub 2006 Nov 3.
PMID: 17082904 [PubMed - indexed for MEDLINE]

5:

New concepts in vaccine development in malaria.

Kanoi BN, Egwang TG.
Curr Opin Infect Dis. 2007 Jun;20(3):311-6. Review.
PMID: 17471043 [PubMed - indexed for MEDLINE]

6:

Release of sequestered malaria parasites upon injection of a glycosaminoglycan.

Vogt AM, Pettersson F, Moll K, Jonsson C, Normark J, Ribacke U, Egwang TG, Ekre HP, Spillmann D, Chen Q, Wahlgren M.
PLoS Pathog. 2006 Sep;2(9):e100.
PMID: 17009869 [PubMed - indexed for MEDLINE]

7:

Pigmented monocytes are negative correlates of protection against severe and complicated malaria in Ugandan children.

Mujuzi G, Magambo B, Okech B, Egwang TG.
Am J Trop Med Hyg. 2006 May;74(5):724-9.
PMID: 16687669 [PubMed - indexed for MEDLINE]

8:

High titers of IgG antibodies against Plasmodium falciparum serine repeat antigen 5 (SERA5) are associated with protection against severe malaria in Ugandan children.

Okech B, Mujuzi G, Ogwal A, Shirai H, Horii T, Egwang TG.
Am J Trop Med Hyg. 2006 Feb;74(2):191-7.
PMID: 16474069 [PubMed - indexed for MEDLINE]

9:

Two mutations in dihydrofolate reductase combined with one in the dihydropteroate synthase gene predict sulphadoxine-pyrimethamine parasitological failure in Ugandan children with uncomplicated falciparum malaria.

Talisuna AO, Nalunkuma-Kazibwe A, Langi P, Mutabingwa TK, Watkins WW, Van Marck E, Egwang TG, D'Alessandro U.
Infect Genet Evol. 2004 Dec;4(4):321-7.
PMID: 15374529 [PubMed - indexed for MEDLINE]

 

10:

The importance and future of malaria research in Africa.

Ntoumi F, Djimde AA, Mbacham W, Egwang T.
Am J Trop Med Hyg. 2004 Aug;71(2 Suppl):IV. No abstract available.
PMID: 15331851 [PubMed - indexed for MEDLINE]

11:

Fine specificity of serum antibodies to Plasmodium falciparum merozoite surface protein, PfMSP-1(19), predicts protection from malaria infection and high-density parasitemia.

Okech BA, Corran PH, Todd J, Joynson-Hicks A, Uthaipibull C, Egwang TG, Holder AA, Riley EM.
Infect Immun. 2004 Mar;72(3):1557-67.
PMID: 14977962 [PubMed - indexed for MEDLINE]

12:

Efficacy of sulphadoxine-pyrimethamine alone or combined with amodiaquine or chloroquine for the treatment of uncomplicated falciparum malaria in Ugandan children.

Talisuna AO, Nalunkuma-Kazibwe A, Bakyaita N, Langi P, Mutabingwa TK, Watkins WW, Van Marck E, D'Alessandro U, Egwang TG.
Trop Med Int Health. 2004 Feb;9(2):222-9.
PMID: 15040559 [PubMed - indexed for MEDLINE]

13:

Genomics research and malaria control: great expectations.

Alibu VP, Egwang TG.
PLoS Biol. 2003 Nov;1(2):E39. Epub 2003 Nov 17. No abstract available.
PMID: 14624242 [PubMed - indexed for MEDLINE]

14:

Intensity of transmission and spread of gene mutations linked to chloroquine and sulphadoxine-pyrimethamine resistance in falciparum malaria.

Talisuna AO, Langi P, Mutabingwa TK, Van Marck E, Speybroeck N, Egwang TG, Watkins WW, Hastings IM, D'Alessandro U.
Int J Parasitol. 2003 Sep 15;33(10):1051-8.
PMID: 13129527 [PubMed - indexed for MEDLINE]

15:

Population-based validation of dihydrofolate reductase gene mutations for the prediction of sulfadoxine-pyrimethamine resistance in Uganda.

Talisuna AO, Langi P, Mutabingwa TK, Watkins W, Van Marck E, Egwang TG, D'Alessandro U.
Trans R Soc Trop Med Hyg. 2003 May-Jun;97(3):338-42.
PMID: 15228255 [PubMed - indexed for MEDLINE]

16:

Serine repeat antigen (SERA5) is predominantly expressed among the SERA multigene family of Plasmodium falciparum, and the acquired antibody titers correlate with serum inhibition of the parasite growth.

Aoki S, Li J, Itagaki S, Okech BA, Egwang TG, Matsuoka H, Palacpac NM, Mitamura T, Horii T.
J Biol Chem. 2002 Dec 6;277(49):47533-40. Epub 2002 Sep 18.
PMID: 12244052 [PubMed - indexed for MEDLINE]

17:

Role of the pfcrt codon 76 mutation as a molecular marker for population-based surveillance of chloroquine (CQ)-resistant Plasmodium falciparum malaria in Ugandan sentinel sites with high CQ resistance.

Talisuna AO, Kyosiimire-Lugemwa J, Langi P, Mutabingwa TK, Watkins W, Van Marck E, Egwang T, D'Alessandro U.
Trans R Soc Trop Med Hyg. 2002 Sep-Oct;96(5):551-6.
PMID: 12474488 [PubMed - indexed for MEDLINE]

18:

Intensity of malaria transmission, antimalarial-drug use and resistance in Uganda: what is the relationship between these three factors?

Talisuna AO, Langi P, Bakyaita N, Egwang T, Mutabingwa TK, Watkins W, Van Marck E, D'Alessandro U.
Trans R Soc Trop Med Hyg. 2002 May-Jun;96(3):310-7.
PMID: 12174786 [PubMed - indexed for MEDLINE]

19:

The Lys-76-Thr mutation in PfCRT and chloroquine resistance in Plasmodium falciparum isolates from Uganda.

Kyosiimire-Lugemwa J, Nalunkuma-Kazibwe AJ, Mujuzi G, Mulindwa H, Talisuna A, Egwang TG.
Trans R Soc Trop Med Hyg. 2002 Jan-Feb;96(1):91-5.
PMID: 11926004 [PubMed - indexed for MEDLINE]

20:

Natural human immunoglobulin G subclass responses to Plasmodium falciparum serine repeat antigen in Uganda.

Okech BA, Nalunkuma A, Okello D, Pang XL, Suzue K, Li J, Horii T, Egwang TG.
Am J Trop Med Hyg. 2001 Dec;65(6):912-7.
PMID: 11791998 [PubMed - indexed for MEDLINE]

21:

Plasmodium falciparum malariometric indices in Apac district, northern Uganda.

Egwang TG, Apio B, Riley E, Okello D.
East Afr Med J. 2000 Aug;77(8):413-6.
PMID: 12862063 [PubMed - indexed for MEDLINE]

22:

Human IgG subclass antibodies to the 19 kilodalton carboxy terminal fragment of Plasmodium falciparum merozoite surface protein 1 (MSP1(19)) and predominance of the MAD20 allelic type of MSP1 in Uganda.

Apio B, Nalunkuma A, Okello D, Riley E, Egwang TG.
East Afr Med J. 2000 Apr;77(4):189-93.
PMID: 12858901 [PubMed - indexed for MEDLINE]

23:

Low birthweight associated with maternal anaemia and Plasmodium falciparum infection during pregnancy, in a peri-urban/urban area of low endemicity in Uganda.

Kasumba IN, Nalunkuma AJ, Mujuzi G, Kitaka FS, Byaruhanga R, Okong P, Egwang TG.
Ann Trop Med Parasitol. 2000 Jan;94(1):7-13.
PMID: 10723519 [PubMed - indexed for MEDLINE]

24:

Use of polymerase chain reaction for accurate follow-up of Loa loa experimental infection in Mandrillus sphinx.

Touré FS, Ungeheuer MN, Egwang TG, Deloron P.
Am J Trop Med Hyg. 1999 Dec;61(6):956-9.
PMID: 10674677 [PubMed - indexed for MEDLINE]

25:

[Comparative analysis of 2 diagnostic methods of human loiasis: IgG4 serology and nested PCR]

Touré FS, Mavoungou E, Deloron P, Egwang TG.
Bull Soc Pathol Exot. 1999 Jul;92(3):167-70. French.
PMID: 10472442 [PubMed - indexed for MEDLINE]

26:

Sequence conservation of repeat 3 region of the gene coding for the 15 kDa polyprotein within human and simian Loa loa.

Toure FS, Leroy EM, Mavoungou E, Egwang TG.
J Med Primatol. 1999 Apr;28(2):57-61.
PMID: 10431694 [PubMed - indexed for MEDLINE]

27:

[Relationship between the intensity of Loa loa filariasis transmission and prevalence of infections]

Toure FS, Deloron P, Egwang TG, Wahl G.
Med Trop (Mars). 1999;59(3):249-52. French.
PMID: 10701202 [PubMed - indexed for MEDLINE]

28:

Human occult loiasis: improvement in diagnostic sensitivity by the use of a nested polymerase chain reaction.

Touré FS, Kassambara L, Williams T, Millet P, Bain O, Georges AJ, Egwang TG.
Am J Trop Med Hyg. 1998 Jul;59(1):144-9.
PMID: 9684643 [PubMed - indexed for MEDLINE]

29:

Human occult loiasis: field evaluation of a nested polymerase chain reaction assay for the detection of occult infection.

Touré FS, Mavoungou E, Kassambara L, Williams T, Wahl G, Millet P, Egwang TG.
Trop Med Int Health. 1998 Jun;3(6):505-11.
PMID: 9657514 [PubMed - indexed for MEDLINE]

30:

IgG4 serology of loiasis in three villages in an endemic area of south-eastern Gabon.

Touré FS, Egwang TG, Millet P, Bain O, Georges AJ, Wahl G.
Trop Med Int Health. 1998 Apr;3(4):313-7.
PMID: 9623933 [PubMed - indexed for MEDLINE]

31:

Detection of Loa loa-specific DNA in blood from occult-infected individuals.

Touré FS, Bain O, Nerrienet E, Millet P, Wahl G, Toure Y, Doumbo O, Nicolas L, Georges AJ, McReynolds LA, Egwang TG.
Exp Parasitol. 1997 Jul;86(3):163-70.
PMID: 9225766 [PubMed - indexed for MEDLINE]

32:

T helper responsiveness in human Loa loa infection; defective specific proliferation and cytokine production by CD4+ T cells from microfilaraemic subjects compared with amicrofilaraemics.

Baize S, Wahl G, Soboslay PT, Egwang TG, Georges AJ.
Clin Exp Immunol. 1997 May;108(2):272-8.
PMID: 9158097 [PubMed - indexed for MEDLINE]

33:

Experimental infection of a nonhuman primate with Loa loa induces transient strong immune activation followed by peripheral unresponsiveness of helper T cells.

Leroy E, Baize S, Wahl G, Egwang TG, Georges AJ.
Infect Immun. 1997 May;65(5):1876-82.
PMID: 9125575 [PubMed - indexed for MEDLINE]

34:

Species-specific sequence in the repeat 3 region of the gene encoding a putative Loa loa allergen: a diagnostic tool for occult loiasis.

Toure FS, Egwang TG, Wahl G, Millet P, Bain O, Georges AJ.
Am J Trop Med Hyg. 1997 Jan;56(1):57-60.
PMID: 9063362 [PubMed - indexed for MEDLINE]

35:

Loa loa: structural diversity of a 15-kDa repetitive antigen.

Ajuh PM, Akue JP, Boutin P, Everaere S, Egwang TG.
Exp Parasitol. 1995 Sep;81(2):145-53.
PMID: 7556556 [PubMed - indexed for MEDLINE]

36:

Evaluation of Onchocerca volvulus-specific IgG4 subclass serology as an index of onchocerciasis transmission potential of three Gabonese villages.

Egwang TG, Duong TH, Nguiri C, Ngari P, Everaere S, Richard-Lenoble D, Gbakima AA, Kombila M.
Clin Exp Immunol. 1994 Dec;98(3):401-7.
PMID: 7994904 [PubMed - indexed for MEDLINE]

37:

High levels of parasite-specific IgG4 in the absence of microfilaremia in Loa loa infection.

Akue JP, Egwang TG, Devaney E.
Trop Med Parasitol. 1994 Sep;45(3):246-8.
PMID: 7899797 [PubMed - indexed for MEDLINE]

38:

Cloning of a cDNA encoding a putative nicotinic acetylcholine receptor subunit of the human filarial parasite Onchocerca volvulus.

Ajuh PM, Egwang TG.
Gene. 1994 Jun 24;144(1):127-9.
PMID: 8026747 [PubMed - indexed for MEDLINE]

39:

Elevated antifilarial IgG4 antibody levels in microfilaremic and microfilaridermic Gabonese adults and children.

Egwang TG, Nguiri C, Kombila M, Duong TH, Richard-Lenoble D.
Am J Trop Med Hyg. 1993 Jul;49(1):135-42.
PMID: 8352386 [PubMed - indexed for MEDLINE]

40:

Cloning and characterization of a Loa loa-specific repetitive DNA.

Egwang TG, Ajuh PM, Akue JP.
Mol Biochem Parasitol. 1992 Dec;56(2):189-96.
PMID: 1484545 [PubMed - indexed for MEDLINE]

41:

The BALB/c mouse as a model for immunological studies of microfilariae-induced pulmonary eosinophilia.

Egwang TG, Kazura JW.
Am J Trop Med Hyg. 1990 Jul;43(1):61-6.
PMID: 2382764 [PubMed - indexed for MEDLINE]

42:

Macaca fascicularis, a nonpermissive host for the human filarial parasite Loa loa.

Pinder M, Leclerc A, Flockhart HA, Egwang TG.
J Parasitol. 1990 Jun;76(3):373-6.
PMID: 2352067 [PubMed - indexed for MEDLINE]

43:

Loa loa: identification of genomic DNA clones expressing recombinant antigens.

Egwang T, Pinder M, Akue JP.
Exp Parasitol. 1990 May;70(4):490-3. No abstract available.
PMID: 2323401 [PubMed - indexed for MEDLINE]

44:

Differential recognition of Loa loa antigens by sera of human subjects from a loiasis endemic zone.

Egwang TG, Dupont A, Leclerc A, Akué JP, Pinder M.
Am J Trop Med Hyg. 1989 Dec;41(6):664-73.
PMID: 2641644 [PubMed - indexed for MEDLINE]

45:

Storage of filarial parasites in CsTFA and precipitation of filarial DNA using MTAB.

Egwang TG, Akue JP, Pinder M.
Parasitol Today. 1989 Nov;5(11):367-9.
PMID: 15463158 [PubMed]

46:

The identification and partial characterization of an immunodominant 29-31 kilodalton surface antigen expressed by adult worms of the human filaria Loa loa.

Egwang TG, Akué JP, Dupont A, Pinder M.
Mol Biochem Parasitol. 1988 Dec;31(3):263-72.
PMID: 3221911 [PubMed - indexed for MEDLINE]

47:

Biochemical and immunochemical characterization of surface and excretory-secretory antigens of Loa loa microfilariae.

Egwang TG, Dupont A, Akué JP, Pinder M.
Mol Biochem Parasitol. 1988 Dec;31(3):251-61.
PMID: 2464765 [PubMed - indexed for MEDLINE]

48:

Identification of a surface antigen on Loa loa microfilariae the recognition of which correlates with the amicrofilaremic state in man.

Pinder M, Dupont A, Egwang TG.
J Immunol. 1988 Oct 1;141(7):2480-6.
PMID: 3049808 [PubMed - indexed for MEDLINE]

49:

The role of rat C3 and C3 receptor-bearing alveolar macrophages in in vitro attrition of infective larvae of Nippostrongylus brasiliensis.

Egwang TG, Gauldie J, Befus AD.
J Parasitol. 1987 Dec;73(6):1270-2..  PMID: 3325625 [PubMed - indexed for MEDLINE]

50:

Immunochemical characterization and biosynthesis of major antigens of iodo-bead surface-labeled Brugia malayi microfilariae.

Egwang TG, Kazura JW.
Mol Biochem Parasitol. 1987 Jan 15;22(2-3):159-68.
PMID: 3574345 [PubMed - indexed for MEDLINE]

51:

Unique characteristics of local responses in host resistance to mucosal parasitic infections.

Befus D, Lee T, Ernst P, Egwang T, McElroy P, Gauldie J, Bienenstock J.
Vet Parasitol. 1986 Mar;20(1-3):175-94. Review.
PMID: 3518214 [PubMed - indexed for MEDLINE]

52:

Activation of alveolar macrophages following infection with the parasitic nematode Nippostrongylus brasiliensis.

Egwang TG, Befus AD, Gauldie J.
Immunology. 1985 Mar;54(3):581-8.
PMID: 3882558 [PubMed - indexed for MEDLINE]

53:

Multinucleate giant cells in murine and rat lungs during Nippostrongylus brasiliensis infections. A study of the kinetics of the response in vivo, cytochemistry, IgG- and C3-mediated functions.

Egwang TG, Richards CD, Stadnyk AW, Gauldie J, Befus AD.
Parasite Immunol. 1985 Jan;7(1):11-8.
PMID: 3991233 [PubMed - indexed for MEDLINE]

54:

Broncho-alveolar leucocyte responses during primary and secondary Nippostrongylus brasiliensis infection in the rat.

Egwang TG, Gauldie J, Befus D.
Parasite Immunol. 1984 May;6(3):191-201.
PMID: 6739118 [PubMed - indexed for MEDLINE]

55:

The role of complement in the induction and regulation of immune responses.

Egwang TG, Befus AD.
Immunology. 1984 Feb;51(2):207-24. Review. No abstract available.
PMID: 6363279 [PubMed - indexed for MEDLINE]

56:

Complement-dependent killing of Nippostrongylus brasiliensis infective larvae by rat alveolar macrophages.

Egwang TG, Gauldie J, Befus D.
Clin Exp Immunol. 1984 Jan;55(1):149-56.
PMID: 6362933 [PubMed - indexed for MEDLINE]

57:

Lack of specificity of the C3-opsonized zymosan reagent for the assay of membrane complement receptors.

Egwang TG, Gauldie J, Befus AD.
J Immunol Methods. 1983 Jul 15;61(2):253-7.
PMID: 6345679 [PubMed - indexed for MEDLINE]

58:

Evaluation of the Cornell-Wisconsin centrifugal flotation technique for recovering trichostrongylid eggs from bovine feces.

Egwang TG, Slocombe JO.
Can J Comp Med. 1982 Apr;46(2):133-7.
PMID: 7093809 [PubMed - indexed for MEDLINE]

59:

Efficiency and sensitivity of techniques for recovering nematode eggs from bovine feces.

 

Egwang TG, Slocombe JO.
Can J Comp Med. 1981 Jul;45(3):243-8.
PMID: 7340910 [PubMed - indexed for MEDLINE]

 

 

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